In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.

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Milk Thistle (Silybum marianum)

Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk ...

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Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle)

Use of the herb milk thistle (Silybum marianum) is widespread, and its chemistry has been studied for over 50 years. However, milk thistle endophytes have not been studied previously for their fungal and chemical diversity. We examined the fungal endophytes inhabiting this medicinal herb to determine: (1) species composition and phylogenetic diversity of fungal endophytes; (2) chemical diversit...

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Antioxidant Activity of Hepatoprotective Silymarin and Silybum marianum L. Extract

The paper presents the antioxidant activity evaluation of Silybum marianum L. extract in comparison with the commercial silymarin standard solution (2 mg/mL) and the time-dependent antioxidant capacity by calculating the free radical 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) reaction rate in the presence of these biosystems. The best result was obtained in the case of S. marianum L. extract, with a...

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Extraction of Silymarin Compounds from Milk Thistle (Silybum Marianum) Seed Using Hot, Liquid Water as the Solvent

High value specialty chemicals are usually obtained from natural products by extracting with generally regarded as safe (GRAS) soh•ents. Because organic solvents are quite often used, high operating and disposal costs often occur. When compared to traditional solvents, water can be viewed as an interesting a/tentative because of its low operating and disposal costs. Milk thistle contains compou...

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Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism.

Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The main component of S. marianum fruit extract (silymarin) is a flavonolignan called silybin, which is not only the major silymarin element but is also the most active ingredient of this extract, which has been confirmed in various studies. This compound belongs...

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ژورنال

عنوان ژورنال: Indian Journal of Pharmacology

سال: 2018

ISSN: 0253-7613

DOI: 10.4103/ijp.ijp_660_16